Facing the unknown. Not knowing what´s next. But then team work, common vision, clear goals, competence, communication. One of Jean-François Clervoy’s messages was also that we have amazing planet what you realize when you see it from far above. And he was definatelly far above. He wish everybody would have a chance at least one time to see Earth from that perspective.
He flew twice aboard Space Shuttle Atlantis and once aboard Discovery for a total of 675 hours in space. Check short video of his speech at Explorers Festival 2013 here https://www.youtube.com/watch?v=s_Z2Oasy-AI.
It was also interested to hear from him that in space, when you want to slow down, you actually need to accelerate.